Bill Sullivan, Indiana University
Black licorice may look and taste like an innocent treat, but this candy has a dark side. On Sept. 23, 2020, doctors reported that black licorice was the culprit in the death of a 54-year-old man in Massachusetts. How could this be? Overdosing on licorice sounds more like a twisted tale than a plausible fact.
I am a toxicologist and author of the book “Pleased to Meet Me: Genes, Germs, and the Curious Forces That Make Us Who We Are.” I have a long-standing interest in how chemicals in food and the environment affect the body and mind.
When something seemingly harmless like licorice is implicated in a death, we are reminded of the famous proclamation by Swiss physician Paracelsus, considered the father of toxicology: “All things are poison, and nothing is without poison; the dosage alone makes it so a thing is not a poison.”
Root of the problem
The unfortunate man who succumbed to excessive black licorice consumption is not alone. There is a smattering of similar case reports in medical journals in which patients experienced a sudden severe increase in blood pressure, muscle breakdown or even death.
Adverse reactions are most frequently seen in people over the age of 40 who are eating far more black licorice than the average person. In addition, they are usually consuming the product for prolonged periods of time. In the 2020 case, the Massachusetts man had been eating a bag and a half of black licorice every day for three weeks.
Licorice is a flowering plant native to parts of Europe and Asia. Its scientific name, Glycyrrhiza, is derived from the Greek words “glykos” (sweet) and “rhiza” (root). People have long used the aromatic and sweet extract from its root as an herbal remedy for a wide variety of health maladies, from heartburn and stomach issues to sore throats and cough. However, there is insufficient evidence that licorice is effective in treating any medical condition.
Glycyrrhizin, also called glycyrrhizic acid, is the chemical in black licorice that gives the candy its signature flavor, but it also leads to its toxic effects.
Glycyrrhizin mimics aldosterone, a hormone your adrenal glands make when your body needs to retain sodium and excrete potassium. Sodium and potassium work together as a kind of cellular battery that drives communication between nerves and the contraction of muscles. Too much glycyrrhizin upsets the balance of these electrolytes, which can raise blood pressure and disturb the heart’s rhythm. Other symptoms of excessive licorice intake include swelling, muscle pain, numbness and headache. Examination of the man who died from consuming too much licorice revealed that he had dangerously low levels of potassium, consistent with glycyrrhizin toxicity.
It should be noted that a number of licorice-based foods do not contain real licorice but use a flavoring substitute called anise oil, which does not pose the dangers discussed here. In addition, despite its name, red licorice rarely contains licorice extract. Instead, red licorice is infused with chemicals that impart its cherry or strawberry flavor.
Products that contain real licorice are usually labeled as such and list licorice extract or glycyrrhizic acid among the ingredients. Be advised that some products, such as black jelly beans or Good & Plenty, are mixtures of different candies that contain both anise oil and licorice extract.
Hidden dangers increase risk
Glycyrrhizin has the distinct licorice flavor and is 50 times sweeter than sugar. It has been used in other types of candy, soft drinks, tea, Belgian beers, throat lozenges and tobacco. The prevalence of glycyrrhizin can make it challenging to keep track of how much has been consumed, and a combination of these products could trigger adverse effects.
Some people take dietary or health supplements that already contain licorice, which increases the risk of toxic effects from eating black licorice candy. Certain medications such as hydrochlorothiazide are diuretics that cause increased urination, which can lower potassium levels in the body. Glycyrrhizin also lowers potassium levels, further disrupting the balance of electrolytes, which can produce muscle cramps and irregular heart rhythms.
People with certain preexisting conditions are more susceptible to black licorice overdose. For example, patients who already have low potassium levels, high blood pressure or heart arrhythmia are likely to have greater sensitivity to the effects of excessive licorice. Those with liver or kidney deficiencies will also retain glycyrrhizin in their bloodstream for longer periods, increasing their risk of experiencing adverse effects.
Safely eating black licorice
If you’re a fan of black licorice, there is no need to ban it from your pantry. Eaten in small quantities from time to time, licorice poses no significant threat to otherwise healthy adults and children.
But it is advisable to monitor your intake. A 2024 study conducted in Sweden found that daily ingestion of 100 mg of licorice, which is considered a safe amount, for two weeks was sufficient to raise blood pressure by an average of 3.1 mm Hg. A quarter of the participants also had elevated blood levels of a protein that is made when the heart is working harder.
Be sure to remind your kids that candy is a “sometimes food,” especially black licorice. The U.S. Food and Drug Administration had issued warnings about the rare but serious effects of too much black licorice, advising that people avoid eating more than 2 ounces of black licorice a day for two weeks or longer. The agency advises that if you have been eating a lot of black licorice and experience an irregular heart rhythm or muscle weakness, stop eating it immediately and contact your health care provider.
Some scientists have further cautioned against the routine use of licorice in the form of a dietary supplement or tea for its alleged health benefits, including the treatment of cough associated with COVID-19 or other respiratory infections. A review article from 2012 warned that “the daily consumption of licorice is never justified because its benefits are minor compared to the adverse outcomes of chronic consumption.”
This article, originally published Oct. 26, 2020, has been updated to include results from a 2024 study.
Bill Sullivan, Professor of Pharmacology and Toxicology, Indiana University
This article is republished from The Conversation under a Creative Commons license. Read the original article.
